Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.

ABSTRACT:

Background

Although highly heritable, few genes have been linked to spontaneous intracerebral hemorrhage (SICH), which does not currently have any evidence-based disease-modifying therapy. Individuals of African ancestry are especially susceptible to SICH, even more so for indigenous Africans. We systematically reviewed the genetic variants associated with SICH and examined opportunities for rapidly advancing SICH genomic research for precision medicine.

Method

We searched the National Human Genome Research Institute-European Bioinformatics Institute (NHGRI-EBI) Genome Wide Association Study (GWAS) catalog and PubMed for original research articles on genetic variants associated with SICH as of 15 June 2019 using the PRISMA guideline.

Results

Eight hundred and sixty-fo

SUBMITTER: Wahab KW 

PROVIDER: S-EPMC7413646 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature