Single-atom doping of MoS₂ with manganese enables ultrasensitive detection of dopamine: Experimental and computational approach.

ABSTRACT: Two-dimensional transition metal dichalcogenides (TMDs) emerged as a promising platform to construct sensitive biosensors. We report an ultrasensitive electrochemical dopamine sensor based on manganese-doped MoS₂ synthesized via a scalable two-step approach (with Mn ~2.15 atomic %). Selective dopamine detection is achieved with a detection limit of 50 pM in buffer solution, 5 nM in 10% serum, and 50 nM in artificial sweat. Density functional theory calculations and scanning transmission electron microscopy show that two types of Mn defects are dominant: Mn on top of a Mo atom (Mn_topMo) and Mn substituting a Mo atom (Mn_Mo). At low dopamine concentrations, physisorption on Mn_Mo dominates. At higher concentrations, dopamine chemisorbs on Mn_topM

SUBMITTER: Lei Y 

PROVIDER: S-EPMC7413726 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature