Open-label Venous Leg Ulcer Pilot Study Using a Novel Autolologous Homologous Skin Construct.

ABSTRACT: Venous leg ulcers (VLUs) are often refractory to compression therapy, and their prevalence is increasing. An autologous homologous skin construct (AHSC) that uses the endogenous regenerative capacity of healthy skin has been developed to treat cutaneous defects, with a single application. The ability of AHSC to close VLUs with a single treatment was evaluated in an open-label, single-arm feasibility study to test the hypothesis that AHSC treatment will result in wound closure by providing healthy autologous tissue to the wound bed.

Methods

Ten VLUs were treated with a single application of AHSC. A 1.5 cm² full-thickness skin harvest from the proximal calf was collected and sent to a Food and Drug Administration-registered facility, where it was processed into AHSC and ret

SUBMITTER: Armstrong DG 

PROVIDER: S-EPMC7413806 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature