Nuclear magnetic resonance and surface-assisted laser desorption/ionization mass spectrometry-based serum metabolomics of kidney cancer.

ABSTRACT: Kidney cancer is one of the most frequently diagnosed and the most lethal urinary cancer. Despite all the efforts made, no serum-specific biomarker is currently used in the clinical management of patients with this tumor. In this study, comprehensive high-resolution proton nuclear magnetic resonance spectroscopy (¹H NMR) and silver-109 nanoparticle-enhanced steel target laser desorption/ionization mass spectrometry (¹⁰⁹AgNPET LDI MS) approaches were conducted, in conjunction with multivariate data analysis, to discriminate the global serum metabolic profiles of kidney cancer (n = 50) and healthy volunteers (n = 49). Eight potential biomarkers have been identified using ¹H NMR metabolomics and nine mass spectral features which differed significantly (p < 0.0

SUBMITTER: Niziol J 

PROVIDER: S-EPMC7413895 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature