A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data.

ABSTRACT: The phosphatidylinositol (PI) cycle is central to eukaryotic cell signaling. Its complexity, due to the number of reactions and lipid and inositol phosphate intermediates involved makes it difficult to analyze experimentally. Computational modelling approaches are seen as a way forward to elucidate complex biological regulatory mechanisms when this cannot be achieved solely through experimental approaches. Whilst mathematical modelling is well established in informing biological systems, many models are often informed by data sourced from multiple unrelated cell types (mosaic data) or from purified enzyme data. In this work, we develop a model of the PI cycle informed by experimental and omics data taken from a single cell type, namely platelets. We were able to make a number of prediction

SUBMITTER: Mazet F 

PROVIDER: S-EPMC7414024 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature