Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans.

ABSTRACT: Humans display reproducible sex differences in cognition and behavior, which may partly reflect intrinsic sex differences in regional brain organization. However, the consistency, causes and consequences of sex differences in the human brain are poorly characterized and hotly debated. In contrast, recent studies in mice-a major model organism for studying neurobiological sex differences-have established: 1) highly consistent sex biases in regional gray matter volume (GMV) involving the cortex and classical subcortical foci, 2) a preponderance of regional GMV sex differences in brain circuits for social and reproductive behavior, and 3) a spatial coupling between regional GMV sex biases and brain expression of sex chromosome genes in adulthood. Here, we directly test translatability of rode

SUBMITTER: Liu S 

PROVIDER: S-EPMC7414084 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature