The TP53 mutation rate differs in breast cancers that arise in women with high or low mammographic density.

ABSTRACT: Mammographic density (MD) influences breast cancer risk, but how this is mediated is unknown. Molecular differences between breast cancers arising in the context of the lowest and highest quintiles of mammographic density may identify the mechanism through which MD drives breast cancer development. Women diagnosed with invasive or in situ breast cancer where MD measurement was also available (n = 842) were identified from the Lifepool cohort of >54,000 women participating in population-based mammographic screening. This group included 142 carcinomas in the lowest quintile of MD and 119 carcinomas in the highest quintile. Clinico-pathological and family history information were recorded. Tumor DNA was collected where available (n = 56) and sequenced for breast cancer predispos

SUBMITTER: Cheasley D 

PROVIDER: S-EPMC7414106 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature