Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth.

ABSTRACT: Starting at birth, the immune system of newborns and children encounters and is influenced by environmental challenges. It is still not completely understood how γδ T cells emerge and adapt during early life. Studying the composition of T cell receptors (TCRs) using next-generation sequencing (NGS) in neonates, infants, and children can provide valuable insights into the adaptation of T cell subsets. To investigate how neonatal γδ T cell repertoires are shaped by microbial exposure after birth, we monitored the γ-chain (TRG) and δ-chain (TRD) repertoires of peripheral blood T cells in newborns, infants, and young children from Europe and sub-Saharan Africa. We identified a set of TRG and TRD sequences that were shared by all children from Europe and Africa. Thes

SUBMITTER: Ravens S 

PROVIDER: S-EPMC7414158 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature