T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system.

ABSTRACT: Genome-wide association studies have identified noncoding variants near TBX3 that are associated with PR interval and QRS duration, suggesting that subtle changes in TBX3 expression affect atrioventricular conduction system function. To explore whether and to what extent the atrioventricular conduction system is affected by Tbx3 dose reduction, we first characterized electrophysiological properties and morphology of heterozygous Tbx3 mutant (Tbx3^+/-) mouse hearts. We found PR interval shortening and prolonged QRS duration, as well as atrioventricular bundle hypoplasia after birth in heterozygous mice. The atrioventricular node size was unaffected. Transcriptomic analysis of atrioventricular nodes isolated by laser capture microdissection revealed hund

SUBMITTER: Mohan RA 

PROVIDER: S-EPMC7414162 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature