Transcriptomic analysis delineates potential signature genes and miRNAs associated with the pathogenesis of asthma.

ABSTRACT: Asthma is a multifarious disease affecting several million people around the world. It has a heterogeneous risk architecture inclusive of both genetic and environmental factors. This heterogeneity can be utilised to identify differentially expressed biomarkers of the disease, which may ultimately aid in the development of more localized and molecularly targeted therapies. In this respect, our study complies with meta-analysis of microarray datasets containing mRNA expression profiles of both asthmatic and control patients, to identify the critical Differentially Expressed Genes (DEGs) involved in the pathogenesis of asthma. We found a total of 30 DEGs out of which 13 were involved in the pathway and functional enrichment analysis. Moreover, 5 DEGs were identified as the hub genes by networ

SUBMITTER: Singh P 

PROVIDER: S-EPMC7414199 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature