Mutation of MDM2 gene in Chinese Han women with idiopathic premature ovarian insufficiency.

ABSTRACT: OBJECTIVE:Recent animal studies have demonstrated that the deletion of mouse double minute 2 (Mdm2) in mice leads to premature ovarian insufficiency (POI). The aim of the present study was to investigate whether mutations in the MDM2 gene contribute to POI in Chinese Han women. METHODS:The coding region of the MDM2 gene was examined in 54 Chinese Han women with idiopathic POI and 54 Han healthy controls. Two known single nucleotide polymorphisms (SNPs), rs937283 in 5'-UTR and rs2870820 in intron 1, were compared between both POI and control groups. RESULTS:There were no significant differences in the genotype distributions or allelic frequencies between the POI and control groups. No plausible causative mutations were identified. CONCLUSION:Our findings suggest that mutations in the coding

SUBMITTER: Li H 

PROVIDER: S-EPMC7414479 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature