CD16 expression on neutrophils predicts treatment efficacy of capecitabine in colorectal cancer patients.

ABSTRACT:

Background

Early detection of capecitabine-resistance could largely increase overall survival of colorectal cancer (CRC) patients. Previous studies suggested examination of immune cells in peripheral blood would help to predict efficacy of chemotherapy.

Methods

We examined the immunological characteristics of peripheral blood in CRC patients with capecitabine treatment. We analyzed the relationships between the abnormal immune cell population in capecitabine-resistance patients and major clinical features. Furthermore, RNA sequencing, analyses of cell surface marker expression and the correlations with other major immune cell populations were performed using this population to explore the possible function of these cells.

Results

The expression level of CD16 on neutro

SUBMITTER: Lu Y 

PROVIDER: S-EPMC7414545 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature