Bioinformatics analysis of differentially expressed genes in subchondral bone in early experimental osteoarthritis using microarray data.

ABSTRACT:

Background

Osteoarthritis (OA) is the most common arthritic disease in humans, affecting the majority of individuals over 65 years of age. The aim of this study is to identify the gene expression profile specific to subchondral bone in OA by comparing the different expression profiles in experimental and sham-operation groups.

Methods

Gene expression profile GSE30322 was downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were obtained by limma package. And Database for Annotation, Visualization and Integrated Discovery (DAVID) databases were further used to identify the potential gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Furthermore, a protein-protein interaction (PPI) network was constructe

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7414553 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature