The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity.

ABSTRACT:

Background

Little is known about the correlation between the melanocortin 4 receptor gene (MC4R) single nucleotide polymorphisms (SNPs) and the risk of obesity. This research sought to test the MC4R rs17782313, rs476828 and rs12970134 SNPs, their haplotypes and gene-environment interactions on the risk of obesity in the Maonan ethnic group, an isolated minority in China.

Methods

A case-control study comprised of 1836 participants (obesity group, 858; and control group, 978) was conducted. Genotypes of the three SNPs were determined by the next-generation sequencing (NGS) technology.

Results

The genotypic frequencies of the three SNPs were different between the obesity and control groups (P <  0.05 for all). The minor allelic frequency of the MC4R rs17782313C, rs476828

SUBMITTER: Wei BL 

PROVIDER: S-EPMC7414557 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature