Quantification of RPE Changes in Choroideremia Using a Photoshop-Based Method.

ABSTRACT:

Purpose

To develop a reliable and efficient method for quantifying the area of preserved retinal pigment epithelium (RPE), facilitating the evaluation of disease progression or response to therapy in choroideremia (CHM).

Methods

The fundus autofluorescence images of CHM patients were captured at baseline and 1 year. A Photoshop-based method was developed to allow the reliable measurement of the RPE area. The results were compared with measurements generated by the Heidelberg Eye Explorer 2 (HEYEX2). The areas measured by two independent graders were compared to assess the test-retest reliability.

Results

By using the Photoshop-based method, the area of the RPE measured from 64 eyes was seen to decrease significantly (P < 0.001) at a rate of 2.57 ± 3.22 mm²

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC7414628 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature