Interpreting MAIA Microperimetry Using Age- and Retinal Loci-Specific Reference Thresholds.

ABSTRACT:

Purpose

Macular Integrity Assessment (MAIA) microperimetry is used widely in clinical trials and routine practice to assess paracentral scotoma. Current interpretation of MAIA is based on an assumed uniform 25 decibel (dB) cutoff for normal function irrespective of subject age and retinal location. We examined this convention by establishing an age- and loci-specific reference in healthy eyes and comparing this to the <25 dB cutoff.

Methods

Retrospective MAIA results from healthy eyes were analyzed for prevalence of loci with <25 dB. At each locus, a new reference cutoff was derived from quantile regression of sensitivity against age at the 2.5th percentile. Two clinical cases of serial MAIA testing were analyzed using the new approach and compared to the <25 dB cutoff.

R

SUBMITTER: Charng J 

PROVIDER: S-EPMC7414638 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature