Depth-Dependent Corneal Biomechanical Properties in Normal and Keratoconic Subjects by Optical Coherence Elastography.

ABSTRACT:

Purpose

Compare depth-resolved biomechanical properties in normal and keratoconic corneas in live human subjects using optical coherence elastography (OCE).

Methods

In a prospective series of normal and keratoconus (KC) eyes, a corneal perturbation was applied by a custom swept-source OCE system using a transparent flat lens coupled to force transducers. Cross-correlation was applied to track frame-by-frame OCT speckle displacement. Regional displacements for the anterior and posterior stroma were plotted in force versus displacement (k) graphs. A spatial biomechanical property ratio (k_a/k_p ) was defined by dividing the maximum total displacement by the maximum force for the anterior (k_a ) and posterior cornea (k_p

SUBMITTER: De Stefano VS 

PROVIDER: S-EPMC7414661 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature