Factors Influencing Retinal Pigment Epithelium-Atrophy Progression Rate in Stargardt Disease.

ABSTRACT:

Purpose

To evaluate demographic, clinical, imaging, and genetic factors associated with retinal pigment epithelium enlargement in Stargardt disease (STGD1) and to measure the agreement between short-wavelength fundus autofluorescence (SW-FAF) and near-infrared fundus autofluorescence (NIR-FAF).

Methods

Retrospective cohort study of patients with STGD1 with ≥2 gradable SW-FAF images. RPE-atrophy areas were measured on SW-FAF and NIR-FAF at each visit and regressed against time to obtain the rate of RPE-atrophy enlargement. Agreement between SW-FAF and NIR-FAF with regards to baseline atrophic areas and rates of enlargement was evaluated. Baseline factors predictive of faster SW-FAF RPE-atrophy enlargement were investigated with linear mixed models.

Results

Fifty-four e

SUBMITTER: Cicinelli MV 

PROVIDER: S-EPMC7414677 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature