OncoPDSS: an evidence-based clinical decision support system for oncology pharmacotherapy at the individual level.

ABSTRACT:

Background

Precision oncology pharmacotherapy relies on precise patient-specific alterations that impact drug responses. Due to rapid advances in clinical tumor sequencing, an urgent need exists for a clinical support tool that automatically interprets sequencing results based on a structured knowledge base of alteration events associated with clinical implications.

Results

Here, we introduced the Oncology Pharmacotherapy Decision Support System (OncoPDSS), a web server that systematically annotates the effects of alterations on drug responses. The platform integrates actionable evidence from several well-known resources, distills drug indications from anti-cancer drug labels, and extracts cancer clinical trial data from the ClinicalTrials.gov database. A therapy-centric cla

SUBMITTER: Xu Q 

PROVIDER: S-EPMC7414679 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature