The genome-wide supported CACNA1C gene polymorphisms and the risk of schizophrenia: an updated meta-analysis.

ABSTRACT:

Background

The CACNA1C gene was defined as a risk gene for schizophrenia in a large genome-wide association study of European ancestry performed by the Psychiatric Genomics Consortium. Previous meta-analyses focused on the association between the CACNA1C gene rs1006737 and schizophrenia. The present study focused on whether there was an ancestral difference in the effect of the CACNA1C gene rs1006737 on schizophrenia. rs2007044 and rs4765905 were analyzed for their effect on the risk of schizophrenia.

Methods

Pooled, subgroup, sensitivity, and publication bias analysis were conducted.

Results

A total of 18 studies met the inclusion criteria, including fourteen rs1006737 studies (15,213 cases, 19,412 controls), three rs2007044 studies (6007 cases, 6518 controls), and t

SUBMITTER: Liu YP 

PROVIDER: S-EPMC7414708 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature