Recurrent sequence evolution after independent gene duplication.

ABSTRACT:

Background

Convergent and parallel evolution provide unique insights into the mechanisms of natural selection. Some of the most striking convergent and parallel (collectively recurrent) amino acid substitutions in proteins are adaptive, but there are also many that are selectively neutral. Accordingly, genome-wide assessment has shown that recurrent sequence evolution in orthologs is chiefly explained by nearly neutral evolution. For paralogs, more frequent functional change is expected because additional copies are generally not retained if they do not acquire their own niche. Yet, it is unknown to what extent recurrent sequence differentiation is discernible after independent gene duplications in different eukaryotic taxa.

Results

We develop a framework that detects patter

SUBMITTER: A von der Dunk SH 

PROVIDER: S-EPMC7414715 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature