Interleukin-6 May Not Affect Bone Resorption Marker CTX or Bone Formation Marker P1NP in Humans.

ABSTRACT:

Context

Interleukin 6 (IL-6) contributes to bone remodeling in preclinical studies. Clinical trials investigating the role of IL-6 in bone remodeling are limited.

Objective

To investigate if IL-6 regulates bone remodeling in humans.

Design

Plasma concentrations of the bone resorption marker carboxy-terminal type I collagen crosslinks (CTX) and of the bone formation marker procollagen type 1 N-terminal propeptide (P1NP) were measured during a mixed-meal tolerance test (MMTT) in 3 placebo-controlled human studies.

Participants

Five healthy individuals participated in study 1; 52 obese individuals, in study 2; and 10 healthy individuals, in study 3.

Interventions

Study 1 was a single-blinded crossover study consisting of a 1-h infusion of saline (placebo) o

SUBMITTER: Lehrskov LL 

PROVIDER: S-EPMC7414920 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature