Neuronal adenosine A_2A receptors signal ergogenic effects of caffeine.

ABSTRACT: Caffeine is one of the most used ergogenic aid for physical exercise and sports. However, its mechanism of action is still controversial. The adenosinergic hypothesis is promising due to the pharmacology of caffeine, a nonselective antagonist of adenosine A₁ and A_2A receptors. We now investigated A_2AR as a possible ergogenic mechanism through pharmacological and genetic inactivation. Forty-two adult females (20.0 ± 0.2 g) and 40 male mice (23.9 ± 0.4 g) from a global and forebrain A_2AR knockout (KO) colony ran an incremental exercise test with indirect calorimetry (V̇O₂ and RER). We administered caffeine (15 mg/kg, i.p., nonselective) and SCH 58261 (1 mg/kg, i.p., selective A_2AR antagonist) 15 min before the open field and e

SUBMITTER: Aguiar AS 

PROVIDER: S-EPMC7415152 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature