Abnormal dynamic functional connectivity in Alzheimer's disease.

ABSTRACT:

Aims

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Previous studies have demonstrated abnormalities in functional connectivity (FC) of AD under the assumption that FC is stationary during scanning. However, studies on the FC dynamics of AD, which may provide more insightful perspectives in understanding the neural mechanisms of AD, remain largely unknown.

Methods

Combining the sliding-window approach and the k-means algorithm, we identified three reoccurring dynamic FC states from resting-state fMRI data of 26 AD and 26 healthy controls. The between-group differences both in FC states and in regional temporal variability were calculated, followed by a correlation analysis of these differences with cognitive performances of AD patients.

Results

SUBMITTER: Gu Y 

PROVIDER: S-EPMC7415210 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature