Application and prospect of adipose stem cell transplantation in treating lymphedema.

ABSTRACT:

Background

Lymphedema is a chronic, debilitating and incurable disease that affects 0.13%-2% of the global population. Emerging evidence indicates that adipose-derived stem cells (ADSCs) might serve as suitable seed cells for lymphatic tissue engineering and lymphedema therapy.

Aim

To summarize applications of ADSCs for treating lymphedema in both animal studies and clinical trials.

Methods

A systematic search was performed on four databases - PubMed, Clinicaltrials.gov, the evidence-based Cochrane Library, and OVID - using the following search string: ("lymphedema" or "lymphoedema" or "lymphangiogenesis") and ("adipose-derived stem cells" or "adipose-derived stromal cells" or "adipose-derived regenerative cells"). A manual search was performed by skimming the referen

SUBMITTER: Li ZJ 

PROVIDER: S-EPMC7415250 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature