Alterations in the Ocular Surface Microbiome in Traumatic Corneal Ulcer Patients.

ABSTRACT:

Purpose

Corneal ulcers are a common eye inflammatory disease that can cause visual impairment or even blindness if not treated promptly. Ocular trauma is a major risk factor for corneal ulcers, and corneal trauma in agricultural work can rapidly progress to corneal ulcers. This study aims to evaluate the changes in the ocular surface (OS) microbiome of patients with traumatic corneal ulcer (TCU).

Methods

Among 20 healthy control (HC) subjects and 22 patients with TCU, 42 eyes were examined to investigate the OS microbial flora using metagenomic shotgun sequencing.

Results

At the taxonomic composition level, our findings showed that dysbiosis (alterations in richness and community structure) occurs in the OS microbiome of patients with TCU. Notably, Pseudomonas was pre

SUBMITTER: Kang Y 

PROVIDER: S-EPMC7415308 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature