Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction.

ABSTRACT:

Purpose

We examined inferior oblique muscles from subjects with over-elevation in adduction for characteristics that might shed light on the potential mechanisms for their abnormal eye position.

Methods

The inferior oblique muscles were obtained at the time of surgery in subjects diagnosed with either primary inferior oblique overaction or Apert syndrome. The muscles were frozen and processed for morphometric analysis of myofiber size, central nucleation, myosin heavy chain (MyHC) isoform expression, nerve density, and numbers of neuromuscular junctions per muscle section.

Results

The inferior oblique muscles from subjects with Apert Syndrome were smaller, and had a much more heterogeneous profile relative to myofiber cross-sectional area compared to controls. Increas

SUBMITTER: Rudell JC 

PROVIDER: S-EPMC7415317 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature