Gut microbiota composition before infection determines the Salmonella super- and low-shedder phenotypes in chicken.

ABSTRACT: Heterogeneity of infection and extreme shedding patterns are common features of animal infectious diseases. Individual hosts that are super-shedders are key targets for control strategies. Nevertheless, the mechanisms associated with the emergence of super-shedders remain largely unknown. During chicken salmonellosis, a high heterogeneity of infection is observed when animal-to-animal cross-contaminations and reinfections are reduced. We hypothesized that unlike super-shedders, low-shedders would be able to block the first Salmonella colonization thanks to a different gut microbiota. The present study demonstrates that (i) axenic and antibiotic-treated chicks are more prone to become super-shedders; (ii) super or low-shedder phenotypes can be acquired through microbiota transfer; (iii) spe

SUBMITTER: Kempf F 

PROVIDER: S-EPMC7415355 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature