Clinical and neuroimaging correlates of progression of mild parkinsonian signs in community-dwelling older adults.

ABSTRACT:

Introduction

Mild parkinsonian signs (MPS) are associated with morbidity. Identification of MPS progression markers may be vital for preventive management, yet has not been pursued. This study aimed to ascertain clinical/neuroimaging features predictive of MPS progression.

Methods

205 participants in the Health ABC Study were included. MPS was defined using published guidelines. MPS progression was evaluated by determining UPDRS-III change between baseline and follow-up ≥2 years later. Standard brain MRI and DTI were obtained at baseline. Correlation coefficients between demographics, vascular risk factors, imaging markers, and UPDRS-III change were adjusted for follow-up time. Linear regression was used to adjust for possible confounders in the relationship between imaging

SUBMITTER: Miller-Patterson C 

PROVIDER: S-EPMC7415586 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature