Novel Variants of <i>ELP2</i> and <i>PIAS1</i> in the Interferon Gamma Signaling Pathway Are Associated with Non-Small Cell Lung Cancer Survival.

ABSTRACT:

Background

IFNγ is a pleiotropic cytokine that plays critical immunomodulatory roles in intercellular communication in innate and adaptive immune responses. Despite recognition of IFNγ signaling effects on host defense against viral infection and its utility in immunotherapy and tumor progression, the roles of genetic variants of the IFNγ signaling pathway genes in survival of patients with cancer remain unknown.

Methods

We used a discovery genotyping dataset from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (n = 1,185) and a replication genotyping dataset from the Harvard Lung Cancer Susceptibility Study (n = 984) to evaluate associations between 14,553 genetic variants in 150 IFNγ pathway genes and survival of non-small cell lung cancer (

SUBMITTER: Zhao YC 

PROVIDER: S-EPMC7415606 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature