Circadian desynchronization alters metabolic and immune responses following lipopolysaccharide inoculation in male mice.

ABSTRACT: Metabolism and inflammation are linked at many levels. Sickness behaviors are elicited by the immune system's response to antigenic stimuli, and include changes in feeding and metabolism. The immune system is also regulated by the circadian (daily) clock, which generates endogenous rhythms, and synchronizes these rhythms to the light-dark cycle. Modern society has resulted in chronic misalignment or desynchronization of the circadian clock and the external environment. We have demonstrated that circadian desynchronization (CD) in mice alters metabolic function, and also affects both peripheral and central immune responses following a low-dose lipopolysaccharide (LPS) challenge. However, it is unclear how this altered immune response impacts sickness behaviors and metabolism following chall

SUBMITTER: Pearson GL 

PROVIDER: S-EPMC7415642 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature