Precipitated Δ9-THC withdrawal reduces motivation for sucrose reinforcement in mice.

ABSTRACT: Withdrawal from Δ⁹-tetrahyrocannibidol (THC) is associated with a host of dysphoric symptoms that increase probability of relapse. To date, many animal models of THC withdrawal rely on withdrawal-induced somatic withdrawal signs leaving withdrawal-suppressed behavior relatively unexplored. As compared with withdrawal-induced behaviors, ongoing behavior that is suppressed by withdrawal is a useful behavioral endpoint because it 1) more effectively models the subjective aspects of withdrawal and 2) identifies pharmacotherapies that restore behavior to baseline levels, rather than eliminate behavior induced by withdrawal. The current study assessed effects of spontaneous and rimonabant-precipitated THC withdrawal in mice responding on a progressive-ratio (PR) schedule of sucrose wa

SUBMITTER: Eckard ML 

PROVIDER: S-EPMC7415667 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature