Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses.

ABSTRACT: Focal radiotherapy can promote cross-presentation of tumor antigens to T cells, but by itself, it is insufficient to induce therapeutically effective T-cell responses. The common gamma-chain cytokine IL15 promotes and sustains the proliferation and effector function of CD8⁺ T cells but has limited activity against poorly immunogenic tumors that do not elicit significant spontaneous T-cell responses. Here, we show that radiotherapy and subcutaneous IL15 had complementary effects and induced CD8⁺ T-cell-mediated tumor regression and long-term protective memory responses in two mouse carcinoma models unresponsive to IL15 alone. Mechanistically, radiotherapy-induced IFN type I production and Batf3-dependent conventional dendritic cells type 1 (cDC1) were required for prim

SUBMITTER: Pilones KA 

PROVIDER: S-EPMC7415682 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature