Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals.

ABSTRACT:

Objective

Skeletal muscle mitochondrial function and energy metabolism displays day-night rhythmicity in healthy, young individuals. Twenty-four-hour rhythmicity of metabolism has been implicated in the etiology of age-related metabolic disorders. Whether day-night rhythmicity in skeletal muscle mitochondrial function and energy metabolism is altered in older, metabolically comprised humans remains unknown.

Methods

Twelve male overweight volunteers with impaired glucose tolerance and insulin sensitivity stayed in a metabolic research unit for 2 days under free living conditions with regular meals. Indirect calorimetry was performed at 5 time points (8 AM, 1 PM, 6 PM, 11 PM, 4 AM), followed by a muscle biopsy. Mitochondrial oxidative capacity was measured in permeabilized mus

SUBMITTER: Wefers J 

PROVIDER: S-EPMC7415921 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature