Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction.

ABSTRACT: Chemokines mediate leukocyte migration and homeostasis and are key targets in inflammatory diseases including atherosclerosis, cytokine storm, and chronic autoimmune disease. Chemokine redundancy and ensuing network robustness has frustrated therapeutic development. Salivary evasins from ticks bind multiple chemokines to overcome redundancy and are effective in several preclinical disease models. Their clinical development has not progressed because of concerns regarding potential immunogenicity, parenteral delivery, and cost. Peptides mimicking protein activity can overcome the perceived limitations of therapeutic proteins. Here we show that peptides possessing multiple chemokine-binding and anti-inflammatory activities can be developed from the chemokine-binding site of an evasin. We use

SUBMITTER: Darlot B 

PROVIDER: S-EPMC7415964 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature