Imaging genomics discovery of a new risk variant for Alzheimer's disease in the postsynaptic SHARPIN gene.

ABSTRACT: Molecular mechanisms underlying Alzheimer's disease (AD) are difficult to investigate, partly because diagnosis lags behind the insidious pathological processes. Therefore, identifying AD neuroimaging markers and their genetic modifiers may help study early mechanisms of neurodegeneration. We aimed to identify brain regions of the highest vulnerability to AD using a data-driven search in the AD Neuroimaging Initiative (ADNI, n = 1,100 subjects), and further explored genetic variants affecting this critical brain trait using both ADNI and the younger UK Biobank cohort (n = 8,428 subjects). Tensor-Based Morphometry (TBM) and Independent Component Analysis (ICA) identified the limbic system and its interconnecting white-matter as the most AD-vulnerable brain feature. Whole-genome analysis rev

SUBMITTER: Soheili-Nezhad S 

PROVIDER: S-EPMC7416020 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature