Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.

ABSTRACT: Hippo signaling is an important regulator of tissue size, but it also has a lesser-known role in tissue morphogenesis. Here we use the Drosophila pupal eye to explore the role of the Hippo effector Yki and its cofactor Mask in morphogenesis. We found that Mask is required for the correct distribution and accumulation of adherens junctions and appropriate organization of the cytoskeleton. Accordingly, disrupting mask expression led to severe mis-patterning and similar defects were observed when yki was reduced or in response to ectopic wts. Further, the patterning defects generated by reducing mask expression were modified by Hippo pathway activity. RNA-sequencing revealed a requirement for Mask for appropriate expression of numerous genes during eye morphogenesis. These included genes impl

SUBMITTER: DeAngelis MW 

PROVIDER: S-EPMC7416169 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature