Plasma and Cellular Forms of Fibronectin as Prognostic Markers in Sepsis.

ABSTRACT:

Background

There is a pressing need for specific prognostic markers that could be used to monitor the severity of sepsis. The aims of our study were to investigate changes in the expression of different molecular forms of fibronectin in sepsis and to assess their relationship to the clinical severity and mortality of patients. Material and Methods. Forms of fibronectin: plasma (pFN), cellular (EDA-FN), FN-fibrin complexes, and fibronectin fragments were analyzed in 71 sepsis patients (survivors and nonsurvivors) and in the control by ELISA and immunoblotting.

Results

The baseline pFN concentration of patients with sepsis was significantly lower than in the control (133.0 mg/L vs. 231.2 mg/L) (P < 0.001), and in nonsurvivors, it was lower than in survivors (106.

SUBMITTER: Lemanska-Perek A 

PROVIDER: S-EPMC7416265 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature