Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome.

ABSTRACT:

Background

Waardenburg syndrome is an uncommon genetic condition characterized by at least some degree of congenital hearing loss and pigmentation deficiencies. However, the genetic pathway affecting the development of stria vascularis is not fully illustrated.

Methods

The transcript profile of stria vascularis of Waardenburg syndrome was studied using Mitf-M mutant pig and mice models. Therefore, GO analysis was performed to identify the differential gene expression caused by Mitf-M mutation.

Results

There were 113 genes in tyrosine metabolism, melanin formation, and ion transportations showed significant changes in pig models and 191 genes in mice models. In addition, there were some spice's specific gene changes in the stria vascularis in the mouse and porcine mode

SUBMITTER: Chen L 

PROVIDER: S-EPMC7416267 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature