Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles.

ABSTRACT:

Background

Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed differences with non-diabetic counterparts.

Methods

This cross-sectional study involved 508 adults with T1DM and 347 controls, recruited from institutions in a Mediterranean region of Spain. Conventional and advanced (assessed by nuclear magnetic resonance [NMR] spectroscopy) lipoprotein profiles were analysed. Crude and adjusted (by age, sex, statin use, body mass index and leukocyte count) comparisons were performed.

Results

The median (interquartile range) age of the study participants was 45 (38-53) years, 48.2% were men. In the T1DM group, the me

SUBMITTER: Amor AJ 

PROVIDER: S-EPMC7416413 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature