Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density.

ABSTRACT: The microtubule cytoskeleton plays critically important roles in numerous cellular functions in eukaryotes, and it does so across a functionally diverse and morphologically disparate range of cell types [1]. In these roles, microtubule assemblies must adopt distinct morphologies and physical dimensions to perform specific functions [2-5]. As such, these macromolecular assemblies-as well as the dynamics of the individual microtubule polymers from which they are made-must scale and change in accordance with cell size, geometry, and function. Microtubules in cells typically assemble to a steady state in mass, leaving enough of their tubulin subunits soluble to allow rapid growth and turnover. This suggests some negative feedback that limits the extent of assembly, for example, decrease in gro

SUBMITTER: Geisterfer ZM 

PROVIDER: S-EPMC7416492 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature