Glucocorticoid receptor sensitivity in early pregnancy in an African American cohort.

ABSTRACT:

Problem

Disruption in homeostatic feedback loops between inflammatory mediators and the hypothalamic-pituitary-adrenal (HPA) axis is a key mechanism linking chronic stress to inflammation and adverse health outcomes, including those occurring during pregnancy. In particular, alterations in glucocorticoid sensitivity may occur as a result of chronic stress, including that due to racial discrimination, and may be implicated in the persistent adverse maternal and infant health outcomes experienced by African Americans. While there are a few large-scale studies in human pregnancy that measure both cytokines and HPA axis hormones, to our knowledge, none directly measure glucocorticoid sensitivity at the cellular level, especially in an African American population.

Method of study

SUBMITTER: Clarke LS 

PROVIDER: S-EPMC7416519 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature