Analyzing DNA methylation patterns in subjects diagnosed with schizophrenia using machine learning methods.

ABSTRACT: Schizophrenia is a common mental disorder with high heritability. It is genetically complex and to date more than a hundred risk loci have been identified. Association of environmental factors and schizophrenia has also been reported, while epigenetic analyses have yielded ambiguous and sometimes conflicting results. Here, we analyzed fresh frozen post-mortem brain tissue from a cohort of 73 subjects diagnosed with schizophrenia and 52 control samples, using the Illumina Infinium HumanMethylation450 Bead Chip, to investigate genome-wide DNA methylation patterns in the two groups. Analysis of differential methylation was performed with the Bioconductor Minfi package and modern machine-learning and visualization techniques, which were shown previously to be successful in detecting and highli

SUBMITTER: Torabi Moghadam B 

PROVIDER: S-EPMC7416578 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature