Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression.

ABSTRACT:

Purpose

Previous sequencing studies revealed that alterations of genes associated with DNA damage response (DDR) are enriched in men with metastatic castration-resistant prostate cancer (mCRPC). BRCA2, a DDR and cancer susceptibility gene, is frequently deleted (homozygous and heterozygous) in men with aggressive prostate cancer. Here we show that patients with prostate cancer who have lost a copy of BRCA2 frequently lose a copy of tumor suppressor gene RB1; importantly, for the first time, we demonstrate that co-loss of both genes in early prostate cancer is sufficient to induce a distinct biology that is likely associated with worse prognosis.

Experimental design

We prospectively investigated underlying molecular mechanisms and genomic consequences of

SUBMITTER: Chakraborty G 

PROVIDER: S-EPMC7416644 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature