The human tissue-resident CCR5⁺ T cell compartment maintains protective and functional properties during inflammation.

ABSTRACT: CCR5 is thought to play a central role in orchestrating migration of cells in response to inflammation. CCR5 antagonists can reduce inflammatory disease processes, which has led to an increased interest in using CCR5 antagonists in a wide range of inflammation-driven diseases. Paradoxically, these antagonists appear to function without negatively affecting host immunity at barrier sites. We reasoned that the resolution to this paradox may lie in the CCR5⁺ T cell populations that permanently reside in tissues. We used a single-cell analysis approach to examine the human CCR5⁺ T cell compartment in the blood, healthy, and inflamed mucosal tissues to resolve these seemingly contradictory observations. We found that 65% of the CD4 tissue-resident memory T (TRM) cell compa

SUBMITTER: Woodward Davis AS 

PROVIDER: S-EPMC7416666 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature