Epigenome-wide analyses identify DNA methylation signatures of dementia risk.

ABSTRACT:

Introduction

Dementia pathogenesis begins years before clinical symptom onset, necessitating the understanding of premorbid risk mechanisms. Here we investigated potential pathogenic mechanisms by assessing DNA methylation associations with dementia risk factors in Alzheimer's disease (AD)-free participants.

Methods

Associations between dementia risk measures (family history, AD genetic risk score [GRS], and dementia risk scores [combining lifestyle, demographic, and genetic factors]) and whole-blood DNA methylation were assessed in discovery and replication samples (n = ~400 to ~5000) from Generation Scotland.

Results

AD genetic risk and two dementia risk scores were associated with differential methylation. The GRS associated predominantly with methylation differenc

SUBMITTER: Walker RM 

PROVIDER: S-EPMC7416667 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature