Ontology highlight
ABSTRACT:
SUBMITTER: Walker RM
PROVIDER: S-EPMC7416667 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Alzheimer's & dementia (Amsterdam, Netherlands) 20200810 1
<h4>Introduction</h4>Dementia pathogenesis begins years before clinical symptom onset, necessitating the understanding of premorbid risk mechanisms. Here we investigated potential pathogenic mechanisms by assessing DNA methylation associations with dementia risk factors in Alzheimer's disease (AD)-free participants.<h4>Methods</h4>Associations between dementia risk measures (family history, AD genetic risk score [GRS], and dementia risk scores [combining lifestyle, demographic, and genetic facto ...[more]