Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study.

ABSTRACT:

Introduction

Prognostication in memory clinic patients with vascular brain injury (eg possible vascular cognitive impairment [VCI]) is often uncertain. We created a risk score to predict poor clinical outcome.

Methods

Using data from two longitudinal cohorts of memory clinic patients with vascular brain injury without advanced dementia, we created (n = 707) and validated (n = 235) the risk score. Poor clinical outcome was defined as substantial cognitive decline (change of Clinical Dementia Rating ≥1 or institutionalization) or major vascular events or death. Twenty-four candidate predictors were evaluated using Cox proportional hazard models.

Results

Age, clinical syndrome diagnosis, Disability Assessment for Dementia, Neuropsychiatric Inventory, and medial temporal

SUBMITTER: Boomsma JMF 

PROVIDER: S-EPMC7416669 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature