Genome-wide heritability analysis of severe malaria resistance reveals evidence of polygenic inheritance.

ABSTRACT:

Background

Estimating single nucleotide polymorphism (SNP)-heritability (h2g) of severe malaria resistance and its distribution across the genome might shed new light in to the underlying biology.

Method

We investigated h2g of severe malaria resistance from a genome-wide association study (GWAS) dataset (sample size = 11 657). We estimated the h2g and partitioned in to chromosomes, allele frequencies and annotations using the genetic relationship-matrix restricted maximum likelihood approach. We further examined non-cell type-specific and cell type-specific enrichments from GWAS-summary statistics.

Results

The h2g of severe malaria resistance was estimated at 0.21 (se = 0.05, P = 2.7 × 10-5), 0.20 (se = 0.05, P = 7.5 × 10-5) and 0.17 (se = 0.05, P = 7.2 × 10-4) in Gam

SUBMITTER: Damena D 

PROVIDER: S-EPMC7416678 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature