Systemic inflammation as fuel for acute liver injury in COVID-19.

ABSTRACT:

Background

A cytokine storm conceivably contributes to manifestations of corona virus disease (COVID-19). Inflammatory cytokines such as interleukin-6 (IL-6) cause acute liver injury while serum detectability indicates systemic inflammation.

Aims

We explored a link between systemic IL-6, related acute phase proteins and liver injury in hospitalized COVID-19 patients.

Methods

655 patients with suspected COVID-19 were screened in the emergency department at the University Hospital of Innsbruck, Austria, between February and April 2020. 96 patients (∼15%) were hospitalized with COVID-19. 15 patients required intensive-care treatment (ICT). Plasma aminotransferases, alkaline phosphatase, bilirubin, and gamma glutamyl transferase, as well as IL-6, C-reactive protein (CRP),

SUBMITTER: Effenberger M 

PROVIDER: S-EPMC7416681 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature