Soy isoflavones interact with calcium and contribute to blood pressure homeostasis in women: a randomized, double-blind, placebo controlled trial.

ABSTRACT:

Background

Estrogens and calcium regulate vascular health but caused adverse cardiovascular events in randomized trials.

Objectives

Whether phytoestrogenic soy isoflavones modulate the physiological effects of calcium on blood pressure was explored.

Design

A double-blind, randomized study assigned 99 premenopausal women to 136.6 mg isoflavones (as aglycone equivalents) and 98 to placebo for 5 days per week for up to 2 years. Blood pressure, serum calcium and urinary excretion of daidzein (DE) and genistein (GE) were measured repeatedly before and during treatment.

Results

Isoflavones did not affect blood pressure per intake dose assignment (i.e. intention-to-treat, n = 197), but significantly affected blood pressure per measured urinary excretion of isoflavones

SUBMITTER: Lu LW 

PROVIDER: S-EPMC7416691 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature